Lacy  Alexander 

photo of Lacy Alexander

Associate Professor of Kinesiology

Contact Information

113 Noll Laboratory
The Pennsylvania State University
University Park PA 16802

814-867-1781

(fax) 814-865-4602

lma191@psu.edu

www.ncbi.nlm.nih.gov/pubmed/?term=Alexander+LM+%5BAuthor%5D

www.ncbi.nlm.nih.gov/pubmed/?term=Holowatz+LA+%5BAuthor%5D

Research Interests

Dr. Alexander’s research interests include examining in vivo and in vitro mechanisms of microvascular dysfunction in cardiovascular disease populations included primary aged, essential hypertension, and hypercholesterolemic humans. Using the cutaneous circulation as a model for examining mechanisms of microvascular dysfunction, the broad focus of her current projects includes examining 1) the roles of arginase in nitric oxide synthase uncoupling in human vasculature with hypercholesterolemia and hypertension, 2) inflammation-induced alteration in vasodilatory signaling with essential hypertension, 3) the role of reactive oxygen species in altering vasoconstriction and vascular remodeling with hypertension, and 4) the effects of common platelet inhibitors (including aspirin and Plavix®) on microvascular function in human skin as they relate to basic mechanisms of skin blood flow and functional thermoregulatory outcomes.

Education

Ph.D., 2007, Kinesiology, The Pennsylvania State University

Specializations

  • Mechanisms underlying vascular dysfunction with cardiovascular disease
  • Pharmacological and lifestyle interventions in vascular dysfunction
  • Control of human skin blood flow

Selected Publications

Book Chapters

Kenney W. L. & L. A. Holowatz. Hypertension. American Council on Exercise Medical Exercise Specialist Manual. Editors, James S. Skinner, Cedric X. Bryant, Sabrena Merrill, Daniel J. Green. ISBN 978-1-890720-52-0, 2015.

Kenney W. L. & L. A. Holowatz. Hypertension. American Counsel on Exercise Advanced Fitness Specialist Reference Manuel. Editor, Cedric X. Bryant, ISBN-13: 978-1890720278, 2008.

 

Journal Articles

Greaney, J.L., Kutz, J., Shank, S., Jandu, S., Santhanam, L, and L.M. Alexander. Impaired hydrogen sulfide-mediated vasodilation contributes to microvascular endothelial dysfunction in hypertensive adults. Hypertension. HYPE201608964R2 Accepted on Feb 17, 2017

Stanhewicz, A.E., Greaney, J.L., Alexander, L.M., and W.L. Kenney. Folic acid supplementation increases cutaneous vasodilator sensitivity to sympathetic nerve activity in older adults. Am J Physiol Regul Integr Comp Physiol. 2017 Feb 22:ajpregu.00493.2016. http://doi:10.1152/ajpregu.00493.2016.

Craighead, D.H., Shank, S.W., Gottschall, J.S., Passe, D.H., Murray, B., Alexander, L.M., and W.L. Kenney. Ingestion of TRP channel agonists attenuates exercise-induced muscle cramps. Muscle Nerve. 2017 Feb 13. http://doi: 10.1002/mus.25611.