Associate Professor of Kinesiology
113 Noll Laboratory
The Pennsylvania State University
University Park PA 16802
Dr. Alexander’s research interests include examining in vivo and in vitro mechanisms of microvascular dysfunction in cardiovascular disease populations included primary aged, essential hypertension, and hypercholesterolemic humans. Using the cutaneous circulation as a model for examining mechanisms of microvascular dysfunction, the broad focus of her current projects includes examining 1) the roles of arginase in nitric oxide synthase uncoupling in human vasculature with hypercholesterolemia and hypertension, 2) inflammation-induced alteration in vasodilatory signaling with essential hypertension, 3) the role of reactive oxygen species in altering vasoconstriction and vascular remodeling with hypertension, and 4) the effects of common platelet inhibitors (including aspirin and Plavix®) on microvascular function in human skin as they relate to basic mechanisms of skin blood flow and functional thermoregulatory outcomes.
Ph.D., 2007, Kinesiology, The Pennsylvania State University
Mechanisms underlying vascular dysfunction with cardiovascular disease
Pharmacological and lifestyle interventions in vascular dysfunction
Control of human skin blood flow
Holowatz, L.A. and W.L. Kenney. Chronic low-dose aspirin therapy attenuates reflex cutaneous vasodilation in middle-aged humans. J Appl Physiol. E-pub Nov 26, 2008.
Holowatz LA, Thompson-Torgerson CS, Kenney WL. The human cutaneous circulation as a model of generalized microvascular function. J Appl Physiol. 105(1):370-372, 2008.
Holowatz, L.A. , and W. L. Kenney. Local ascorbate administration augments NO- and non-NO-dependent reflex cutaneous vasodilation in hypertensive humans. Am J Physiol Heart Circ Physiol. Aug; 293( 2): H1090-6, 2007.
Holowatz, L. A. , and W. L. Kenney. Up-regulation of arginase activity contributes to attenuated reflex cutaneous vasodilatation in hypertensive humans. J Physiol. 581(Pt 2):863-72, 2007.
Holowatz, L. A., C. S. Thompson, and W. L. Kenney. Acute ascorbate supplementation alone or combined with arginase inhibition augments reflex cutaneous vasodilation in aged human skin. Am J Physiol Heart Circ Physiol, 291, H2965-2970, 2006.
Holowatz, L. A., C. S. Thompson, and W. L. Kenney. L-arginine supplementation or arginase inhibition augments reflex cutaneous vasodilatation in aged human skin. J Physiol 574 (Pt 2):573-81, 2006.
- Domains of Health and Behavior