The consequences of over-nutrition and the stress of "western diets" related to lipid mediators and a global shift of dietary fatty acids; identifying markers of disease and better ways to prevent or manage disease.
- Nutritional Sciences - NUTR
- Graduate Program
University Park, PA 16802
Lipid mediators are bioactive metabolites of dietary fatty acids. They act on tissues to alter many disease-related functions, including the stiffness of blood vessels and the body's response to stress.
Most investigations focus on the actions of individual lipid mediators, however over-nutrition and the stress of "western diets" is characterized by a global shift of dietary fatty acids, not a shift in any single fatty acid. The consequence of multiple changes in fatty acids is a corresponding change in the array of lipid mediators produced. We seek to understand disease-related functional changes in the context of globally changes and use them to identify markers of disease and better ways to prevent or manage disease.